Dr. Iris Shichor, Co-Founder and CEO, SipNose - Technology Innovators" /> Dr. Iris Shichor, Co-Founder and CEO, SipNose - Technology Innovators" />
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HEALTH TECH

SipNose – Providing a Breakthrough in Neurology

Dr. Iris Shichor, Co-Founder and CEO, SipNose
Dr. Iris Shichor, Co-Founder and CEO, SipNose
sipnose

SipNose - Providing a Breakthrough in Neurology

Diligent, hardworking, optimistic, and creative – these qualities could not be better attributed to Dr. Iris Shichor, who has soared new heights in her professional life. As the CEO of SipNose, an innovative medical platform enabling new intranasal treatments for a wide variety of neurological disorders including the innovative nose to brain delivery route, Dr. Iris brings extensive experience in leading research and development programs and managing product development projects from concept to product.

A PhD holder from the Hebrew University of Jerusalem, and a post-doctoral fellowship at Harvard -MIT, at Robert Langer’s lab, her expertise in biochemistry, neuroscience and drug delivery systems are unmatched. In an interview, she speaks on an array of subjects. Excerpts from an interview:

SipNose – The Story Behind

Says Dr. Shichor that unlike other companies in the field, that either focus on the drug formulation development or on the device technology development, SipNose combines the formulation expertise and its innovative mechanism in products that result in synergy for optimized delivery.

She notes that her background in Neuroscience, exposed her to the existence of the physiological window at the upper nasal cavity, that allow the non-invasive delivery from the nose to the brain. “This amazed me and my co-founder at SipNose, Mr. Dani Shahaf. We understood that the gap between the vision of delivering drugs to the brain, and finding a solution, is a mechanical challenge more than anything else. This is when we decided to take on the challenge and combine our expertise of Neuroscience, drug delivery and mechanical engineering into a medical device solution for delivering drugs to the brain.” Dr. Shichor adds that they developed their technology to answer the need, through mechanical eyeglasses. “We learned the nasal cavity structure and challenges and provided a solution that can overcome its natural barriers (as of the nose natural role as a filter) to effectively deliver drugs to the deeper areas of the nasal cavity. From there physiology allows the diffusion into the brain.”

The Drug Delivery Platform

SipNose innovative delivery platform aims to overcome the drawbacks of intranasal delivery products in the market by presenting a new generation of nasal delivery platform and devices. The SipNose platform utilizes a unique combination of parameters and forces, that produce aerosol with unique characteristics. The outcome is a highly reproducible dosing, high absorption of drugs that results in very high efficacy, altogether with an improved user experience.

“The above resulted in SipNose becoming a leader in the most challenging area of nasal delivery which is the Direct Nose to Brain delivery” observes Dr. Shichor. This growing area encounter the unmet need of non-invasively delivering drugs to the brain and Central Nervous System, as this route of delivery bypasses the Blood Brain Barrier (BBB) that blocks the delivery of ~98% of existing drugs in market. “SipNose platform allows the delivery of a wide range of liquid formulations (low to very high viscosity) and powder formulations, and suits small molecules as well as biologics such as proteins, steam cells and more” she adds.

Challenges Galore

Dr. Shichor cites challenges like tough regulation requirements, the constant pressure to be innovative and novel in a very competitive environment. She also cites fund raising and constant competition as merely a few of the challenges of working in this industry. She recommends treating small companies at first stages differently than large pharma companies, for example, a shorter and less expensive regulation processes, that will allow faster progress of small companies to the stage in which they can understand if it is worthwhile investing the efforts and funds in the continuation of a project. In general, Dr. Shichor states, the market should be more open to innovation. Large pharmaceutical players should take greater part in supporting new and advantageous technologies in the field in earlier stages than they do today.

Most Memorable Moment of Success

According to Dr. Shichor, one of the greatest moments of success at SipNose was the understanding that the company has a solution that can improve and change the lives of patients.  For example, when a patient can get a life-saving treatment outside of the hospital, with the SipNose device, instead of the need to be taken into the ER to get the treatment. this is a gamechanger. SipNose’ first clinical proof of concept study, which was in anti-epileptic seizures was the first success in this sense. “I remember how excited we were, that not only we got the positive assurance of the feasibility of intranasal administration of drugs to patients that are under epileptic seizures with our innovative device, but also the efficiency and the fast time to activity that was revealed in this study, as those perfectly fitted this concept.” Epilepsy is only the tip of the iceberg. Today we are also active in the field of optic nerve preservation, psychiatric disorders, dementia and more, she says.

A Piece of Advice

“Take any challenge as an opportunity to grow. Be creative and believe in your product and in your team. Choose professionals that are as motivated as you to bring a change to the healthcare industry” signs of Dr. Iris.

Dr. Iris Shichor, Co-Founder and CEO, SipNose

Company: SipNose

Website: www.sipnose.com

Management:  Dr. Iris Shichor, Co-Founder and CEO

Founded Year: 2012

Headquarters: Yoqneam Ilit, Israel

Description: SipNose develops an innovative nasal delivery device for local, systemic, and central nervous system indications.

HEALTH TECH

Albert Health: A holistic approach for chronic diseases

Recai Serdar Gemici, CEO Albert Health
Recai Serdar Gemici, CEO

About Recai Serdar Gemici

Company: Albert Health

Website: www.albert.health

Management:  CEO

Founded Year: 2018

Headquarters: Hertfordshire, United Kingdom

Description: Albert is an evidence-based multi-chronic disease management platform that leverages AI.

Recai Serdar Gemici, CEO

Albert Health: A holistic approach for chronic diseases

Serdar is the CEO of Albert Health, a voice-based health assistant that enables people to manage their chronic diseases. The company intends to design disease-specific experience and help pharma companies to increase medication adherence in their therapeutic areas. In an interview, Serdar speaks on an array of topics. Excerpts:

Founding of Albert Health

 Says Serdar that chronic diseases are, in fact, a part of all our lives, even if we don’t experience them firsthand. These diseases are health problems that affect individuals throughout their entire lives and require careful attention and care. According to the World Health Organization, chronic diseases are responsible for an average of 86% of deaths and 77% of health expenses. Effective tracking, treatment, and management of chronic diseases help slow down their progression. “Our specific focus is on treatment adherence in chronic diseases. Treatment adherence maximizes treatment effectiveness, while non-adherence is the leading cause of poor treatment outcomes. 50% of individuals with chronic diseases do not adhere to their treatment plans, resulting in the death of 200,000 people annually in Europe alone.” Albert Health assists patients in understanding their chronic disease and help them embrace the treatment adherence required by that chronic condition.

 Post Covid-19 – Challenges galore in healthcare

In the post-pandemic era, healthcare providers should prioritize a holistic approach that combines technological advancements with personalized patient care to create a more resilient and efficient healthcare ecosystem, suggests Serdar. However, he adds that one of the key challenges is to ensure effective population health management. “Healthcare providers need to shift their focus beyond treating illnesses to proactively manage the health of both sick and healthy individuals. This involves allocating more resources to preventive medicine, early intervention, and lifestyle management. Additionally, technology adoption remains a critical factor in realizing the full benefits of healthcare innovations.” It is essential for healthcare providers to   facilitate the seamless integration of technology into clinical workflows and patient experiences. This can be achieved by identifying the most convenient use cases for both doctors and patients and employing user-friendly interfaces, such as voice technology, to enhance engagement and usability.

Albert Health’s platform   for digital natives- Features

Albert is an evidence-based, multi-chronic disease management platform that leverages AI.   With Albert, patients of all ages can easily manage their treatments, granting access to personalized treatment management for users from all socio-economic backgrounds, and helping improve their quality of life by acting as a mediator for lifestyle changes.

The platform offers personalized chronic disease management programs for various chronic conditions, including diabetes, asthma, hypertension, MS, HIV, and cancer. Patients can receive online consultations from healthcare professionals through Albert. They can set medication reminders, access medication prospectuses, and receive alerts about medication interactions. They can also set reminders for tasks like drinking water and measurements. Patients can store their health documents and measurements in one place, effectively track their treatment progress and health status, and share health data with their loved ones and healthcare professionals.

Offering a voice platform that patients can consult anytime, anywhere, Albert’s Natural Language Processing (NLP) technology, users can verbally ask questions on their minds. Through disease-specific trained language models, Albert understands users’ needs based on their conditions and provides them with the most suitable answers. The entire Albert platform is developed to easily adapt and be configured to meet different disease needs” adds Serdar.

Leadership traits

Curiosity, according to Serdar is one of the driving forces in the entrepreneurship journey. “I also think the traits of order and discipline are must-haves in entrepreneurship. Additionally, the perseverance instilled by discipline encourages both my personal growth and Albert Health’s achievements.

Lessons learnt from the healthcare sector

“From my journey in the healthcare sector, I’ve learned the invaluable importance of being patient centric. This principle underscores the fact that the goal of any healthcare endeavour should be improving the lives of the patients we serve. Alongside this, another critical point is to always consider the health economics aspect.”

 Albert Health – The future ahead

Albert aims to reach more patients suffering from chronic diseases and help them with most reliable and scientifically backed support. We have dedicated ourselves to becoming an essential part of the lives of patients with chronic diseases.”

Since the future of digital health is evidence-based, the firm aims to prove the benefits they provide to patients and health economics through clinical studies. “In this direction, we have committed ourselves to become a global digital health company that offers evidence-based digital therapeutic solutions, that have proven clinical value and economic benefits, and are prescription and reimbursable. Digital Therapeutics (DTx) are evidence-based digital solutions that can prevent, treat, or manage diseases, either alongside traditional treatment methods or as substitutes. We aim for our DTx solutions to be prescribed and reimbursed, just like medication. In addition, we want to support our patients not only digitally but also physically. In the long run, we aspire to open our own clinics to enhance the delivery of healthcare services even more. By collaborating with expert healthcare professionals in our clinics, we aim to provide more comprehensive health services and directly and effectively respond to the needs of our users.

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HEALTH TECH

Bold Health: Creating holistic gut care

Elena Mustatea, Co-founder & CEO, Bold Health

About Elena Mustatea

Company: Bold Health

Website: www.bold.health

Management:  Co-founder & CEO

Founded Year: 2018

Headquarters: London, UK

Description: Bold Health is a specialty telemedicine company that offers multi-disciplinary care for Gastrointestinal (GI) conditions.

Elena Mustatea, Co-founder & CEO

Bold Health: Creating holistic gut care

Elena Mustatea is the Co-founder and CEO of Bold Health, a digital health company helping individuals improve their digestive health with holistic gut care. Elena received the 21st Century Icon Technology Innovator award and was named in the Forbes’ Europe 30 Under 30 List, while her company Bold Health has been recognised for digital health innovation in numerous industry awards. Previously Elena worked in venture capital as investor with leading European VC fund Atomico, in investment banking at J.P. Morgan and Goldman Sachs, in management consulting at Oliver Wyman, and ran a media business in university. She also started a political activism group to represent the tech industry voice during Brexit called TechTogether UK, and represented her birth country in Children’s Parliament of the World. Elena is a Romanian native and received her Bachelor of Arts from Dartmouth College in New Hampshire, USA.

In an interview, she speaks on an array of topics. Excerpts:

Conception of Bold Health 

Elena explains that when she started Bold Health, she was coming out of her own health journey of healing her gut and her relationship with food. “After suffering an intestinal infection and as a result of poor lifestyle choices such as stressful job, poor sleep, drinking alcohol and eating too much raw food, I suffered long term digestive issues such as abdominal pain, food sensitivities, bloating and fatigue.” She added that she was quick enough to recognise the benefits and the need for holistic, root-cause medicine that brings together Western science with traditional approaches like food and plant medicine, nervous system regulation and human support in the form of specialist experts. “We brought all these together in an online platform, conveniently accessible and adapted to the needs of the modern individual who is empowered to have agency over their health. We wanted individuals to feel bold and empowered about their health, supported and hopeful!

With Bold, patients feel in expert hands, validated and understood in their health journey, supported with leading edge science-based solutions they can trust from a team of medical professionals, to solve not just their digestive health, but boost their mood and overall wellbeing.”

Healthcare industry- challenges galore 

Says this healthcare professional that in the post pandemic world, health workers face ever increasing patient demand, burdensome regulation and administrative tasks. “The opportunity is to deliver virtual-first, stepped care that triages patients into the right service (which is not always seeing a human, but could be going through a digital program), using data at every step of the care journey, automatising steps wherever possible, and making things easier for the provider by for example using AI to write the charts.” She noted that our providers have to freedom to work from where and when they want to, can spend sufficient time with the patient, and leverage content and tracking in between visits to maximize self-management and treatment impact outside the provider visit.

Key features of Bold Health’s comprehensive platform 

Bold Health’s comprehensive platform offers a set of self-help tools, patient education, psychobehavioral techniques, relaxation and lifestyle change, and where necessary medication and supplements, to support patients in healing their gut for good. “Depending on the symptoms and condition, we also offer the services of a team of clinicians specialized in treating gut health such as doctors or specialist nurses, registered dietitians, health coaches or therapists, who can support patients with the different aspects of holistic care. By bringing together different disciplines and types of therapies, the patient can get the combined benefit to transform their digestive health.”

Leadership traits 

Bold Health has become a global leader in digestive health in a few short years due to a unique combination of daring to think differently about the patient care experience, while staying loyal to medical evidence. “I am focused on service and solving human problems from a place of integrity and care. I also love technology’s ability to make healthcare data-informed, accessible, convenient, so I like to bring in the value of innovation and human-centered design.”

A word of advice for entrepreneurs 

Elena urges startups to not go into regulated spaces, unless you have very strong, unique, defendable IP and solid financial backing. Do a business where there is a clear existing business model and you know for sure someone will pay for your product or service. Develop health economics / ROI evidence early.

Bold Health- The way ahead

We will be expanding our multi-disciplinary, stepped care model across other chronic conditions outside GI, to be able to treat the whole person including when there are multiple co-occurring illnesses that will all benefit from lifestyle improvement, nervous system regulation, dietary improvements and expert medical advice.

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HEALTH TECH

DocHQ: Empowering healthcare through technology

Madhur Srivastava, Founder, CEO- DocHQ

About Madhur Srivastava

Company: DocHQ

Website: www.dochq.co.uk

Management: Founder, CEO

Founded Year: 2018

Headquarters: Worcester , England

Description: DocHQ combines medical expertise with AI technology to make healthcare accessible to all, from virtual physiotherapy to home health testing and travel health.

DocHQ: Empowering healthcare through technology

DocHQ is an UK employee benefits provider, that helps people make informed health choices and inspire them to improve their quality of life. The health service provider is a specialist medical technology provider aimed at enhancing employee wellbeing at work and home – connecting businesses, providers, and consumers through technology. From employee health and wellness programs to physical wellness in the workplace and at home, DocHQ combines medical expertise and technology to offer wellbeing services and solutions in a post-pandemic world.

Founding of DocHQ

In 2018, tech professional Madhur Srivastava embarked on a journey to revolutionise the approach to employee benefits, insurance, and healthcare through the lens of technology. This led to the birth of DocHQ, a platform initially designed as a user-friendly telehealth service, before expanding its reach to include unique offerings such as travel healthcare for those journeying abroad.

“In the healthcare market, we recognised a pressing need for integrated, scalable solutions that facilitate better patient-provider communication. DocHQ emerged as a response to bridge these gaps and offer a comprehensive healthcare solution designed especially for the digital age” observes Madhur.

Healthcare industry- challenges galore 

The pandemic accelerated the digital shift, but it also highlighted the importance of data security, a human and personal touch in digital environments, and the need to constantly validate the accuracy of tech solutions, especially in healthcare, opines. “Providers must prioritise these aspects to maintain trust and deliver efficient care in the post-pandemic era.”

DocHQ’s comprehensive platform – Features 

Central to DocHQ’s offerings is ‘DocHQ Physio’, an AI-driven platform tailored for today’s digital landscape. This platform provides comprehensive patient assessments, both physically and online, leading to personalised exercise prescriptions, explains Madhur. “As patients engage with their rehab exercises via our platform, the AI-movement tracking technology delivers visual and audio real-time feedback, optimising their movements for therapeutic benefit. Behind the scenes, the system gathers vital data, offering physiotherapists a rich tapestry of insights to monitor and guide a patient’s progression.” A standout feature is its asynchronous progress tracking, where physiotherapists can adjust exercise regimens based on the collected data, ensuring a continually optimised recovery journey. With DocHQ Physio, the practitioners have melded the precision of AI with the indispensable human touch of physiotherapy, ensuring comprehensive, effective and dynamic care tailored for the digital native.

Leadership traits

Madhur believes in collaborative leadership, listening to his team, valuing feedback, and fostering a culture of innovation. He feels that all these have played a part in the trajectory of both his personal journey and that of DocHQ. “I’d add that I’m curious and ever adaptive. The healthcare landscape is ever evolving, and staying curious allows me to anticipate changes and adapt swiftly.”

Word of caution for healthcare entrepreneurs

“First and foremost, always keep the customer at the centre of everything you do. In the race to innovate, it’s easy to get swept up in the allure of new technologies and cutting-edge solutions. However, as a CEO, I’ve seen first-hand that the most enduring and impactful solutions are those that directly enhance customer care and experience.” Also, while agility is a strength in the start-up world, in healthcare it’s vital to balance it with thoroughness and caution. Due diligence, customer safety and regulatory compliance are not just boxes to tick, but are foundational to building trust and longevity in this sector. Stay customer centric. Technology and innovation are essential, but they should always serve the primary goal of enhancing customer care and experience.

One principle stands out unequivocally: healthcare is fundamentally about people. Whether we’re discussing patients, their families, or the professionals serving them, every decision we make, every innovation we introduce, and every change we implement should have the wellbeing and betterment of individuals as its guiding star.

DocHQ – Forging ahead

At the forefront of the firm’s innovation pipeline is the integration of behavioural science into the DocHQ Physio AI system. “We believe that the most effective healthcare is holistic, addressing not just the physical but also the emotional and psychological aspects of wellbeing. We’re exploring how subtle behavioural cues, discerned from voice and visual data, can provide insights into a customer’s mental state.” This has enabled them to send targeted nudges to users, not just improving the information they receive but potentially influencing positive health outcomes. Imagine a system that, beyond diagnosing physical ailments, can also sense distress or anxiety and respond empathetically. “By bridging the realms of AI, behavioural science and healthcare, we’re taking a leap towards a future where digital health solutions truly understand and cater to the multifaceted nature of human health.”

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